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Journal of the Serbian Chemical Society 2002 Volume 67, Issue 7, Pages: 465-471
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Antimalarial peroxides: The first intramolecular 1,2,4,5-tetraoxane

Opsenica Dejan M., Pocsfalvi Gabriella, Milhous Wilburk K., Šolaja Bogdan A.

An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL).

Keywords: tetraoxane, malaria, peroxide, steroid, intramolecular