Journal of the Serbian Chemical Society 2004 Volume 69, Issue 11, Pages: 855-859
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Synthesis of the 4’-desmethoxy analogue of RU79115
Mušicki Branislav, Periers Anne-Marie, Tessot Nicole, Klich Michel
The synthesis, and biological activity in vitro of the 4’-desmethoxy analogue (3) of RU 79115 (2) is described. Comparison of the biological activity of the two analogues clearly indicated the importance of the 4’-methoxy group in conferring good gyrase B inhibitory activity as well as antibacterial activity.
Keywords: structure-activity, inhibitor, gyrase B, antibacterial, sugar, L-arabinose, coumarin