Archives of Biological Sciences 2011 Volume 63, Issue 2, Pages: 333-343
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The influence of extracellular matrix composition on the pathogenesis of coronary atherosclerosis
Tanasković Irena, Lačković Vesna, Gluvić Z., Lačković Milena, Nešić Vesna, Stanković Vesna, Labudović-Borović Milica, Radović S., Ašanin B.
The modern concept of the development of atherosclerosis implies that the
underlying pathogenesis of this disease is vascular remodeling as a response
of the vessel wall to hypertension associated with hyperlipidemia and
subsequent inflammation. However, even though this disease has been
investigated for decades, both from a basic and clinical research aspect,
there are still many doubts as to what the initial phase of the disease is.
In contemporary literature there are an increasing number of papers that
stress the importance of the extracellular matrix (ECM) of the blood vessels
connective tissue, particularly proteoglycans, in the formation of early
atherosclerotic lesions of human coronary arteries.
Keywords: Atherosclerosis, extracellular matrix, coronary artery, immunohistochemistry, ultrastructure