Medicinski pregled 2012 Volume 65, Issue 5-6, Pages: 191-195
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Age-related skin changes
Levakov Aleksandra, Vučković Nada, Đolai Matilda, Mocko-Kaćanski Mihaela, Božanić Snežana
Age-related skin changes can be induced by chronological ageing, manifested
in subcutaneous fat reduction, and photo-ageing eliciting increased elastotic
substance in the upper dermis, destruction of its fibrilar structure,
augmented intercellular substance and moderate inflammatory infiltrate.
Forty-five biopsy skin samples of the sun-exposed and sun-protected skin were
analyzed. The patients were both males and females, aged from 17 to 81 years.
The thickness of the epidermal layers and the number of cellular living
layers is greater in younger skin. The amount of keratohyaline granules is
enlarged in older skin. Dermoepidermal junction is flattened and the presence
of elastotic material in the dermis is pronounced with age. The amount of
inflammatory infiltrate is increased, the fibrous trabeculae are thickened in
older skin and the atrophy of the hypodermis is observed. Chronological
ageing alters the fibroblasts metabolism by reducing their life span,
capacity to divide and produce collagen. During ageing, the enlargement of
collagen fibrils diminishes the skin elasticity.
Keywords: Skin Aging, Skin + physiopathology, Adolescent, Adult, Middle Aged, Aged, Female, Male, Ultraviolet Rays, Sunlight + adverse effects, Collagen, Elastic Tissue, Dermis, Epidermis