Journal of the Serbian Chemical Society 2009 Volume 74, Issue 6, Pages: 677-688
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Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites

Odović Jadranka, Aleksić Mirjana, Stojimirović Biljana, Milojković-Opsenica Dušanka, Tešić Živoslav

The separation and chromatographic behaviour of five ACE (angiotensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship between the RM values and the composition of employed mobile phase was obtained. The hydrophobicity parameters 0M R and C0 were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipophilicity of the studied ACE inhibitors and their metabolites, previously estimated by reversed-phase chromatography.

Keywords: ACE inhibitors, normal-phase thin-layer chromatography, hydrophobicity

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