Journal of the Serbian Chemical Society 2004 Volume 69, Issue 11, Pages: 981-990
doi:10.2298/JSC0411981T
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Stereoselective synthesis of α-hydroxy-β-amino acids: The chiral pool approach

Tasić Gordana, Matović Radomir V., Saičić Radomir N.

A method for the stereoselective homologation of -amino acids into syn-α-hydroxy-β-amino acids is described, based on the conversion of stereoisomeric cyanohydrins into trans-oxazolines. The synthetic potential of the method is illustrated in the enantioselective formal synthesis of Bestatin.

Keywords: amino acids, cyanohydrins, bestatin, AHPA, oxazoline

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