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Medicinski pregled 2010 Volume 63, Issue 5-6, Pages: 380-386
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Tyrosine kinases in etiopathogenesis and therapy of malignant diseases: c-kit activating mutations

Stankov Karmen, Bogdanović Gordana, Popović Stevan

Introduction. In the last 15 years, the introduction of molecular biology methods and techniques for identifying mutations and measuring gene expression levels of mutated genes since recently, have enabled precise molecular diagnostics, classification and assessment of prognosis and therapeutic response of malignant disease to specific therapies. The increased knowledge of the cancer genome and the introduction of multiple new technologies in cancer research have significantly improved the drug discovery process, leading to key success in targeted cancer therapeutics, including tyrosine kinase inhibitors. Tyrosine kinase inhibitors are the molecular targeted neoadjuvant and adjuvant therapy of various malignancies. Many more results which are expected from ongoing trials are necessary to specify the appropriate dosages, stages at which to start the treatment, and which therapeutic combinations to apply.

Keywords: Protein-Tyrosine Kinases, Hematologic Neoplasms, Leukemia, Receptor Protein-Tyrosine Kinases, Proto-Oncogene Proteins c-kit, Protein Kinase Inhibitors

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