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Journal of the Serbian Chemical Society 2004 Volume 69, Issue 11, Pages: 949-953
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Kinetics of the reaction of 5-substituted orotic acids with diazodiphenylmethane

Jovanović Bratislav Ž., Assaleh Fathi H., Marinković Aleksandar D.

Rate konstants for the reaction of eight 5-substituted orotic acids with diazodiphenylmethane (DDM) in dimethylformamide (DMF) were determined at 30 ºC by the known spectrophotometricmethod. The determined rate constants were correlated with the equations: logk2 = ασ1+βσR+h logk2 = ασ1+βσR+ψν+h to detect the presence and investigate the influence of both electrical and steric substituent effects. The obtained results show that the electrical effect (the localized – field and delocalized – resonance) is predominant and that the steric effect, althought present, is releatively small in this reaction.

Keywords: orotic acids, diazodiphenylmethane, reaction kinetics dimethylformamide