Archives of Biological Sciences 2011 Volume 63, Issue 3, Pages: 563-569
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The protective effect of curcumin against sodium fluoride-induced oxidative stress in rat heart

Nabavi S.F., Nabavi S.M., Ebrahimzadeh M.A., Eslami Sh., Jafari N., Moghaddam Hajizadeh A.

In the present study the cardioprotective effects of curcumin, a herbal polyphenolic compound, against sodium fluoride (NaF)-induced toxicity in rat heart was evaluated. Fifty rats were divided into five experimental groups containing 10 rats each. Group I received standard water and diet and was used as a normal group; groups II and III were pretreated with curcumin intraperitoneally for 7 days prior to NaF intoxication. Group IV was pretreated with vitamin C, a standard antioxidant, intraperitoneally for 7 days prior to NaF intoxication and used as a positive control group. The animals in group V were intoxicated with NaF for the same time and used as a control group. There was a significant increase in lipid peroxidation along with a decrease in superoxide dismutase activity in the homogenates of tissues of the NaF-treated animals. Curcumin pretreatment in animals prior to fluoride intoxication normalized the levels of biochemical parameters measured.

Keywords: Curcumin, oxidative stress, sodium fluoride, enzymatic antioxidant

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