Journal of the Serbian Chemical Society 2011 Volume 76, Issue 6, Pages: 823-830
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An efficient, microwave-assisted, one-pot synthesis of novel 5,6,7,8-tetrahydroquinoline-3-carbonitriles

Dodiya Dipti K., Ram Haresh K., Trivedi Amit R., Shah Viresh H.

An efficient, microwave-assisted synthesis of novel 2-alkoxy- 5,6,7,8-tetrahydroquinoline-3-carbonitriles, which have not hitherto been reported, via reactions of cyclohexanone and arylidene malononitriles in the corresponding alcohols in presence of sodium is described. All the newly synthesized compounds were characterized by the IR, 1H-NMR, 13C-NMR and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

Keywords: 2-Alkoxy-tetrahydroquinoline-3-carbonitriles, quinoline-3-carbonitriles, one-pot synthesis, microwave-assisted synthesis, cyclohexanone, arylidene malononitriles

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