Journal of the Serbian Chemical Society 2004 Volume 69, Issue 11, Pages: 919-922
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7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity
Opsenica Igor, Terzić Nataša A., Opsenica Dejan M., Milhous Wilbur K., Šolaja Bogdan A.
Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetraoxa-dispiro Š188.8.131.52Ćhexadecane-3-carboxamide being as active as artemisinin.
Keywords: mixed tetraoxane, malaria, Plasmodium falciparum, gem-dihydroperoxide