Journal of the Serbian Chemical Society 2012 Volume 77, Issue 6, Pages: 741-750
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Improved synthesis and in vitro study of antimicrobial activity of α,β-unsaturated and α-bromo carboxylic acids
Vitnik Vesna D., Milenković Marina T., Dilber Sanda P., Vitnik Željko J., Juranić Ivan O.
A series of α,β-unsaturated and α-bromo carboxylic acids were identified as
potent antimicrobial agents. Antimicrobial activity was evaluated using broth
microdilution method. All acids 1-12 exhibit a significant activity against
nine laboratory control strains of bacteria and two strains of yeast Candida
albicans. The tested acids were efficiently prepared by optimized
phase-transfer-catalyzed (PTC) reactions of ketones with bromoform and
aqueous lithium hydroxide in alcoholic solvent with TEBA as catalyst.
Keywords: antimicrobial activity, one-pot synthesis, ketones, bromoform