Hemijska industrija 2011 Volume 65, Issue 1, Pages: 87-91
doi:10.2298/HEMIND100908070A
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The qualitative determination of oseltamivir phosphate in Tamiflu® capsule by cyclic voltammetry

Avramov-Ivić Milka L., Petrović Slobodan D., Mijin Dušan Ž., Drljević-Đurić Katica M.

A gold electrode was applied in the voltammetric determination of oseltamivir phosphate standard in 0.05 M NaHCO3. Oseltamivir phosphate as a standard and as a component of Tamiflu® capsule exhibited the identical cyclic voltammogram. The peaks originated from excipients in capsule do not appear under the applied electrochemical conditions. The electrochemical method for the qualitative determination of oseltamivir phosphate in Tamiflu® capsule by cyclic voltammetry was developed. The presence of oseltamivir phosphate as standard and as a content of Tamiflu® capsule in electrolyte as well as their concentrations were simultaneously checked by HPLC. The lack of the current/concentration dependency was established. The not pretreated glassy carbon electrode cannot be used for the determination of oseltamivir phosphate under identical experimental conditions presented for gold electrode.

Keywords: oseltamivir phosphate, Tamiflu®, capsule, cyclic voltammetry, HPLC

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