Journal of the Serbian Chemical Society 2004 Volume 69, Issue 11, Pages: 919-922
doi:10.2298/JSC0411919O
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7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity

Opsenica Igor, Terzić Nataša A., Opsenica Dejan M., Milhous Wilbur K., Šolaja Bogdan A.

Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetraoxa-dispiro Š5.2.5.2Ćhexadecane-3-carboxamide being as active as artemisinin.

Keywords: mixed tetraoxane, malaria, Plasmodium falciparum, gem-dihydroperoxide

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