Archives of Biological Sciences 2010 Volume 62, Issue 2, Pages: 223-230
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The role of FasR/FasL system in pathogenesis of myeloprolyferative neoplasms

Spasovski Vesna, Tosić Natasa, Kostić Tatjana, Zukić Branka, Stojiljković Maja, Čolović Milica, Pavlović Sonja

Myeloproliferative neoplasms (MPN) are hematological malignancies characterized by uncontrolled cell proliferation and impaired apoptosis. The FasR/FasL system is involved in the control of apoptosis in different cell types. Here we have investigated the role of FasR/FasL in the pathogenesis of MPNs. We compared FasR/FasL expression between MPN patients (24) and healthy individuals using the real-time PCR assay. We found an increase of FasR expression in MPN patients. No difference was detected in FasL expression. Mutation V617F in the JAK2 gene, a hallmark of MPN, was detected in 13/24 patients. We found that neither FasR nor FasL expression were related to the presence of JAK2 V617F mutation.

Keywords: Myeloproliferative neoplasms, FasR/FasL, JAK2 V617F mutation