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Journal of the Serbian Chemical Society 2004 Volume 69, Issue 11, Pages: 861-869
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Synthesis of 5-azaandrostane-3β, 17β-diol protected at the 17-hydroxyl group

Pavlović Vladimir D., Dabović Milan M., Martinović Saša, Lorenc Ljubinka B., Kalvoda Jaroslav

In the present paper, the preparation of 3β-hydroxy-17β-dimethyl-tert-butylsilyloxy- 5-azaandrostane (15) in fourteen steps is described. B-nor-17-oxoandrost- 5-en-3β-yl acetate (1)1,2 was used as the starting material, which was transformed to the key intermediate of the synthesis, B-nor-17β-dimethyl-tert-butylsilyloxyandrost- 4-en-3β-yl acetate (7).

Keywords: 5-azasteroids, B-nor-17-oxoandrost-5-en-3-yl acetate, 3β-hydroxy-17β-dimethyl-tert-butylsilyloxy-5-azaandrostane