Zbornik Matice srpske za prirodne nauke 2011 Issue 121, Pages: 19-26
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Susceptibility to antifungal agents of Candida spp. from blood and feces collected in Novi Sad in 3-year period (2008-2010)
Jelesić Zora Z., Medić Deana D., Mihajlović-Ukropina Mira M., Jevtić Marija, Gusman Vera P., Radosavljević Biljana J., Milosavljević Biljana T.
Candidemia is an important emerging nosocomial infection in patients with
risk factors. Candida species from nonsterile sites can give insight into the
characteristics of strains that may cause invasive disease. The aim of this
study was to evaluate antifungal susceptibility of Candida blood and fecal
isolates in Novi Sad, Vojvodina. During a 3-year period (2008 to 2010), 424
isolates of Candida spp. were collected, 30 bloodstream isolates and 394
strains from fecal samples. In vitro susceptibility of these isolates to five
antifungal agents was established using commercial ATB FUNGUS 3
(Bio-Mérieux). Predominant species was Candida albicans (6 isolates from
blood and 269 from feces). Resistance to one or more antifungal agents was
less common in Candida albicans (3.63%) than in other species (24.83%).
Resistance to itraconazole was the most commonly found in both groups of
isolates, 9.64% strains from feces and 20% from blood samples. Twelve
isolates were multiply resistant, usually to fluconazole, itraconazole, and
voriconazole. Resistance to amphotericine B was extremely rare. Although
resistance to antimycotics of Candida spp. is rare at present, continued
surveillance of antifungal susceptibility is necessary in order to monitor
trends, and to choose the right empiric therapy.
Keywords: antifungal susceptibility, candidemia, Candida spp.