Journal of the Serbian Chemical Society 2012 Volume 77, Issue 6, Pages: 725-731
doi:10.2298/JSC110715219A
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Synthesis and in vitro anti breast cancer activity of some novel 1,5-benzothiazepine derivatives

Ameta K.L., Rathore Nitu S., Kumar Biresh

The title compounds 3a-j, substituted 1,5-benzothiazepines were synthesized by the condensation of variously substituted chalcones 1 and 2- aminothiophenol 2 via conventional as well as non-conventional inorganic solid support microwave irradiation methods. The non-conventional protocol offers several advantages such as simple procedure, fast reaction rate, mild reaction conditions and improved yields compared to conventional methods. The structures of the products 3a-j were established by elemental analysis, FTIR, 1H-NMR, 13C-NMR and mass spectroscopic studies. The synthesized compounds have also been evaluated for the cytotoxicity against human breast cancer cell line MDA-MB-435 with some exhibiting in vitro anti-breast cancer activities.

Keywords: 1,5-benzothiazepines, 2-aminothiophenol, chalcones, anti-breast cancer activity