Archive of Oncology 2010 Volume 18, Issue 1-2, Pages: 32-35
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Antiestrogen therapy in recurrent ovarian cancer resulting in 28 months of stable disease: A case report and review of the literature

Kothari Rajul, Argenta Peter, Fowler Jeffrey, Carter Jori, Shimp William

Hormonal therapy for adjuvant treatment of ovarian cancer may provide a low toxicity option in some patients with refractory disease. A 53 year-old patient with stage IIIC papillary serous ovarian cancer previously treated with multiple chemotherapy regimens with platinum-resistant disease was treated with antiestrogen therapy for 28 months before requiring reinstitution of cytotoxic chemotherapy. Hormonal therapy may be effective in a subset of epithelial ovarian cancer patients with endocrine sensitivity and should be considered in the treatment of platinum-resistant patients.

Keywords: Ovarian Neoplasms, Antineoplastic Agents, Hormonal, Selective Estrogen Receptor Modulators, Tamoxifen, Aromatase

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