Journal of the Serbian Chemical Society 2012 Volume 77, Issue 6, Pages: 741-750
doi:10.2298/JSC111104016V
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Improved synthesis and in vitro study of antimicrobial activity of α,β-unsaturated and α-bromo carboxylic acids

Vitnik Vesna D., Milenković Marina T., Dilber Sanda P., Vitnik Željko J., Juranić Ivan O.

A series of α,β-unsaturated and α-bromo carboxylic acids were identified as potent antimicrobial agents. Antimicrobial activity was evaluated using broth microdilution method. All acids 1-12 exhibit a significant activity against nine laboratory control strains of bacteria and two strains of yeast Candida albicans. The tested acids were efficiently prepared by optimized phase-transfer-catalyzed (PTC) reactions of ketones with bromoform and aqueous lithium hydroxide in alcoholic solvent with TEBA as catalyst.

Keywords: antimicrobial activity, one-pot synthesis, ketones, bromoform