Acta veterinaria 2002 Volume 52, Issue 5-6, Pages: 361-368
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Has asialoglycoprotein receptor (ASGP-R) a role to play in binding and processing of different parasites?
Baričević Ivona I., Čuperlović Margita, Sofronić-Milosavljević Ljiljana Đ., Vićovac-Panić Ljiljana M.
Liver asialoglycoprotein receptor (ASGP-R), which specifically recognizes and binds galactose and N-acetyl galactosamine, has been implicated in binding and endocytosis of glycoproteins. Therefore, the possibility that it may have a role in contacting and processing pathogenic organisms was investigated. The interaction in vitro between ASGP-R and surface oligosaccharide structures of Echinococcus granulosus and Trichinella spiralis was studied by immunohistochemical methods. Specific binding of ASGP-R to ligands on the surface protoscolex of E. granulosus was demonstrated. To the contrary, ASGP-R bound ligand(s) of T. spiralis stihocytes, while a staining reaction was absent from the parasite cuticle. These results show that ASGP-R could take part in binding to and retention of E. granulosus in liver cells, thus contributing to its hepatotropic activity.
Keywords: asialoglycoprotein receptor (ASGP-R), Echinococcus granulosus, oligosaccharide ligand, Trichinella spiralis
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