doiSerbia

Rare locations of metastastatic renal cell carcinoma: Presentation of three cases

Milović Novak (Department of Urology, Military Medical Academy, Belgrade + Faculty of Medicine of the Military Medical Academy, University of Defense, Belgrade)
Lazić Miodrag (Department of Urology, Medical Center „Dr D. Mišović-Dedinje“, Belgrade + Faculty of Medicine, Belgrade)
Aleksić Predrag (Department of Urology, Military Medical Academy, Belgrade + Faculty of Medicine of the Military Medical Academy, University of Defense, Belgrade)
Radovanović Dragan (Department of Surgery, Medical Center „Dr D. Mišović-Dedinje“, Belgrade)
Bančević Vladimir (Department of Urology, Military Medical Academy, Belgrade + Faculty of Medicine of the Military Medical Academy, University of Defense, Belgrade)
Savić Slaviša (Department of Urology, Medical Center „Dr D. Mišović-Dedinje“, Belgrade)
Stamenković Dušica (Department of Anesthesia and Intensive Care, Military Medical Academy, Belgrade)
Spasić Dušan (Department of Surgery, Medical Center „Dr D. Mišović-Dedinje“, Belgrade)
Košević Branko (Department of Urology, Military Medical Academy, Belgrade)
Perović Dragoljub (Clinic of Urology and Nephrology, Clinical Center of Montenegro, Podgorica, Montenegro)
Jovanović Mirko (Department of Urology, Military Medical Academy, Belgrade)

Introduction. Metastatic renal cell carcinoma (RCC) frequently spreads not only to neighboring lymph nodes, but also to distant organs, including the lungs, liver, bones and brain. Case report. We presented three cases of RCC with colon metastasis. In the first, 63-year-old patient, after left nephrectomy followed with lyphadenectomy in paraaortic lymph node, left hemicolectomy was done due to RCC metastasis in rectosigmoid colon. In the second, 35-year-old patient, left radical nephrectomy was followed two years later with partial right nephrectomy, lung metastasectomy, small bowel and coecum resection and right orchiectomy all as separate procedures in different time intervals. The patient died from brain and bone metastases two years after the first surgery. The third, 35-year-old patient, had right nephrectomy followed by repeted lymphadenectomies after 6, 12 and 24 months. Four years later RCC spreaded to coecum and right hemicolectomy was performed. Conclusion. RCC treated with nephrectomy should be carefully followed up with imaging methods as a proper treatment of RCC metastases to distant organs could be important for a patient survival.

Keywords: carcinoma, renal cell, neoplasm metastasis, urologic surgical procedures, treatment outcome